Curriculum Vitae - Charles Bugg 

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CURRICULUM VITAE

NAME:                                 Charles Edward Bugg

BORN:                                 June 5, 1941, Durham, North Carolina, USA

HOME ADDRESS:              303 Dexter Avenue, Birmingham, AL 35213

BUSINESS ADDRESS:       BioCryst Pharmaceuticals, Inc.

                                             2190 Parkway Lake Drive

                                             Birmingham, Alabama 35244

TELEPHONE/FAX:             Tel: 205-542-2320; Fax: 205-444-4640

FAMILY:                               Wife: Barbara Bradshaw Bugg of Winston-Salem, NC

                                             Children:         Jeannie Bugg Walston, born June 1, 1967

                                                                     Elizabeth Bugg Holloway, born December 30,1969

                                                                     Charles Edward Bugg, Jr., born January 5,1971

EDUCATION:                      A.B., Duke University, Durham, North Carolina, 1962

                                               Major: Chemistry; Minor: Mathematics

                                               Ph.D., Rice University, Houston, Texas, 1965

                                               Physical Chemistry

POSTGRADUATE              Postdoctoral Research Fellow, California Institute of Technology,

TRAINING:                          1965-1966,1967-1968

RESEARCH AND/OR PROFESSIONAL EXPERIENCE:

Non-executive Chairman, BioCryst Pharmaceuticals, Inc.,

January - May 2007, prior to retiring from the company

Professor Emeritus, Department of Biochemistry and Molecular Genetics, The University

of Alabama at Birmingham, 1994-Present

Chairman and Chief Executive Officer, BioCryst Pharmaceuticals, Inc.,

Birmingham, Alabama, 1994-2006

The University of Alabama at Birmingham:

Professor Emeritus, Department of Biochemistry and Molecular Genetics, 1994-Present

Director, Center for Macromolecular Crystallography, 1985-1993

Senior Scientist, Center for AIDS Research, 1989-1993

Professor, Department of Chemistry, 1991-1993

Professor, Department of Biochemistry; Associate Director and Senior Scientist, Comprehensive Cancer Center; Senior Scientist, Research Center in Oral Biology, 1975-1993

Associate Professor, Department of Biochemistry; Scientist, Comprehensive Cancer Center;

Scientist, Research Center in Oral Biology, 1973-1974

Assistant Professor, Department of Biochemistry; Investigator, Research Center in Oral Biology, 1968-1972

Visiting Professor, Protein Crystallography, University of Oxford, England, 1974-1975, 1981

Postdoctoral work on the crystal structure of compounds related to the nucleic acids, California Institute of Technology with Dr. R.B. Corey and Dr. R.E. Marsh, 1965-1966, 1967-1968

Research Chemist with E.I. du Pont De Nemours and Company. Studies of the structures of synthetic polymers, 1966-1967

HONORS AND APPOINTMENTS:

1963-1965                             National Aeronautics and Space Administration Fellowship

1965-1966                             California Institute of Technology Postdoctoral Fellowship

1967-1968                             California Institute of Technology Postdoctoral Fellowship

1968                                       National Institutes of Health Postdoctoral Fellowship

1977-1989                              Editorial Board, Journal of Crystallographic and Spectroscopic Research

1984-1992                              Member, U.S. National Committee for Crystallography, National

                                               Research Council

1984-1993                              NIH Molecular and Cellular Biophysics Study Section

1986                                       Vice-President, American Crystallographic Association

1986-1989                              Chairman, Biotechnology Discipline Working Group, Universities

                                               Space Research Association

1986-1994                              Consultant, Schering-Plough Research Institute

1987                                       President, American Crystallographic Association

1987                                       Member, Committee on Industrial Applications of the

                                               Microgravity Environment, Space Applications Board, National

                                               Research Council

1984-1987                              Co-Editor, Acta Crystallographica

1986-1993                              Consultant, BioCryst Pharmaceuticals, Inc.

1987-1996                              Editor-in-Chief, Acta Crystallographica; Chairman, Commission

                                               on Journals, International Union of Crystallography

1987-1988                              President, BioCryst Pharmaceuticals, Inc.

1988-1994                              Member, Visiting Committee in Biology, Brookhaven National

                                               Laboratory

1988-1993                              Consultant, Eastman Kodak Company

1988-1993                              Member, NASA Space Station Science and Applications Advisory

                                               Subcommittee

1988-1989                              Member, Space Applications Board, National Research Council

1989-1993                              Chairman, Scientific Advisory Board, BioCryst Pharmaceuticals,

                                               Inc.

1989-1992                              Vice-Chairman, U.S. National Committee for Crystallography,

                                               National Research Council

1989-1995                              Member, Core Users Committee for the Structural Biology Center,

                                               Advanced Photon Source, Argonne National Laboratory

1992                                       Chairman, Brookhaven Protein Data Bank Advisory Board

1993-Present                          Member, Phi Kappa Phi Honor Society

1993                                       Recipient, NASA Public Service Medal for significant scientific

                                               and administrative contributions to NASA's Protein Crystal

                                               Growth Program

1993                                       University of Alabama Medical Center Distinguished Faculty

                                               Lecturer

1994-1996                              Chairman, U.S. National Committee for Crystallography, National

                                               Research Council

1994                                       Recipient, Milstein Award of the International Society for

                                               Interferon and Cytokine Research

PROFESSIONAL ORGANIZATIONS:

Alabama Academy of Sciences

American Association for the Advancement of Science

American Chemical Society

American Crystallographic Association

Federation of American Societies for Experimental Biology

RESEARCH INTERESTS:

Crystallographic studies of biological systems; protein crystallography; protein crystal growth processes; applications of protein crystallography in drug design and protein engineering; molecular modeling; x-ray diffraction studies of the structures of compounds of biological interest.